![]() Pregnancy Teratogenic Effects Category CĪnimal reproduction studies have not been conducted with Nystatin Oral Suspension. There also have been no studies to determine mutagenicity or whether this medication affects fertility in males or females. No long-term animal studies have been performed to evaluate carcinogenic potential. Carcinogenesis, Mutagenesis, Impairment of Fertility Discontinue treatment if sensitization or irritation is reported during use. This medication is not to be used for the treatment of systemic mycoses. The preparation is contraindicated in patients with a history of hypersensitivity to any of its components. Nystatin Oral Suspension is indicated for the treatment of candidiasis in the oral cavity. ![]() Indications and Usage for Nystatin Oral Suspension Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses. Nystatin acts by binding to sterols in the cell membrane of susceptible Candida species with a resultant change in membrane permeability allowing leakage of intracellular components. Generally, resistance does not develop in vivo. Candida albicans demonstrates no significant resistance to nystatin in vitro on repeated subculture in increasing levels of nystatin other Candida species become quite resistant. ![]() ![]() Nystatin is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi. In patients with renal insufficiency receiving oral therapy with conventional dosage forms, significant plasma concentrations of nystatin may occasionally occur. Most orally administered nystatin is passed unchanged in the stool. Gastrointestinal absorption of nystatin is insignificant. Related/similar drugs fluconazole, nystatin, clotrimazole, Diflucan, itraconazole, miconazole, Mycostatin Nystatin Oral Suspension - Clinical Pharmacology Pharmacokinetics ![]()
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![]() If you treasure jewelry that is made by hand, in a careful, thoughtful manner, you have come to the right place. From concept to completion all settings are handcrafted and never utilize purchased mass-produced components. Why is a Madelynn Cassin Piece so Special? Each setting is hand carved in wax, cast in metal, and hand polished, prepped, soldered and set in our workshop in Keene, NH. Sterling Silver Blue Topaz Rings, Kohls Enjoy free shipping and easy returns every day at Kohls. ![]() Because of this, we use only alloys that are 100% recycled, ethically sourced gemstones, and utilize compostable, plant based packaging. Ring in Tarnish Free Recycled Sterling Silver, Blue Cocktail Ring Made To Order 10mm Bright Swiss Blue- London Blue Topaz gemstone ring, 10mm (almost 1/2 an. 14k Gold Sky Blue Topaz East West Bezel Set Octagon Ring 219.99 Compare At 285 See Similar Styles Made In Italy 14kt Gold Braided Ring 179.99 Compare At 275 See Similar Styles Made In Italy Set Of 3 14k Gold Tricolor Rings 99.99 Compare At 150 See Similar Styles Made In India 14kt Gold Rose Quartz Baguette Cluster Ring 479. Sustainability is super important, as the effects of mining for precious materials can devastate communities unnecessarily. This labor of love has grown from a small workspace on a three-season porch to a bustling workshop in an old mill building, where Madelynn continues to handmake objects that help people feel beautiful, loved and express their personalities. These mini works of art start from a block of wax that she then carefully carves into the bold yet delicate and feminine creations that bare her name. Madelynn's designs are inspired by large, naturally occurring colored gemstones and the way they sparkle in the sun. ![]() ![]() This small, independently owned business grew from a love of gemstones and a passion for making. Madelynn Cassin Designs has been selling on ETSY since 2008 under the shop name Onegarnetgirl. ![]() ![]() ![]() Most image capture devices (such as digital cameras) that output JPG creates files in the Exif format, the camera industry standardized for metadata interchange.Īpple iOS (iOS), Apple Photos (Mac), Dropbox (Windows, Mac, Linux, iOS, Android)Īpple Safari, Google Chrome, Mozilla Firefox, Internet Explorer, Adobe Photoshop, Paint Shop Pro, the GIMP, ImageMagick, IrfanView, Pixel image editor, Paint.NET, Xara Photo & Graphic Designer. Select the Google Account where you want to sync HEIC photos, then tap the 'Upload' button to complete photos syncing. Image files that employ JPG compression are commonly called "JPG files" and are stored in variants of the JIF image format. Step 1: Firstly, open the Photos app on your iPhone > select the photos, then hit the share icon at the bottom left corner and select Google Drive. Luckily, you can disable saving images as HEIC on an iOS 11 device by going to Settings > Camera > Formats > Most Compatible, which will force iOS 11 to save images in the JPEG format. Step 1 Upload heic-file (s) Select files from Computer, Google Drive, Dropbox, URL or by dragging it on the page. Third-party apps or computer programs can still have difficulties interpreting HEIC files, though. However, HEIC files still have compatibility issues, even though they are already posted and saved to social media or cloud storage as JPG images since they are automatically converted. With transparency and the ability to store more than one image, HEIC files can also contain 16-bit colors, whereas JPG files can only support 8-bit. The lossy compressed HEIC format is based on HEVC (High-Efficiency Video Compression), also developed by MPEG. JPG typically achieves 10:1 compression with little perceptible loss in image quality. The degree of compression can be adjusted, allowing a selectable tradeoff between storage size and image quality. JPG is a commonly used method of lossy compression for digital images, particularly those produced by digital photography. Haga clic en el Añadir HEIC en la interfaz, busque y seleccione todas las imágenes HEIC que desea cambiar y ábralas. Furthermore, it stores information about image editing like rotation and cropping, which enables the user to revert the changes later on. Paso 1 Agregar imágenes HEIC Inicie el mejor convertidor de HEIC a JPG después de instalarlo en su PC. You can resize output photo (if you dont select, output photos size is. You can choice output format is JPG, PNG, or BMP. Furthermore, HEIC files can contain several images which fit Apple's "Live Photo" functionality. Click 'Open File' and choice your HEIC need to view or convert. As a result, it's smaller in size with comparable quality while also supporting transparency. Being the new default or standard image format for iOS 11 devices, HEIC was designed to replace the JPG format. The HEIC format was developed by MPEG (Moving Picture Experts Group), otherwise known for video and audio formats such as MP3 or MP4. Click the 'Choose Files' button to select multiple files on your computer or click the dropdown button to choose an online file from URL, Google Drive or Dropbox. It is also known under the acronym of HEIF, which stands for High-Efficiency Image Format. HEIC is the new standard image format introduced by Apple with its 2017 update from iOS 10 to iOS 11. ![]() ![]() ![]() *Once you have been fingerprinted, please bring the receipt as proof to Joanne German in 3S – room 209. Dive into the research topics of Security assessment for intentional island operation in modern power system. PETS registration can sometimes take a few days to complete so give yourself a few days prior to planning your trip to Court Street. The HR Connect Walk-in Center is located at 65 Court Street in Brooklyn, NY 11201 and is open Monday through Friday from 9 am to 4:30 pm. Note: You must complete all of the Applicant Gateway forms and fingerprinting within the 10 business days of the PETS registration, otherwise your account will be deactivated and your nomination will be withdrawn. The cost of fingerprinting is $130 payable to NYCDOE by personal check, money order, credit and debit card (except American Express). Go to Court Street with the following: Fingerprint Referral form, student ID.They managed to clear the wild vegetation and build walls with their bare. This email will contain additional forms that need to be filled out, and a Fingerprint Referral Form. Residents of the surrounding area used the unusual island for agricultural purposes. Once your information is entered into PETS, you will receive a confirmation email and be directed to log into the DOE’s Applicant Gateway.Optional: the school you will be observing/student teaching in.The oval-shaped island of Baljenac is covered. Located off the coast of Croatia, in the Adriatic Sea, Baljenac is a tiny island covered by a series of dry-stone walls that make it look like a giant fingerprint when seen from above. You can register by sending an email to: and request that you be added to the CSI roster as a fieldwork observer. Baljenac Croatia’s Famous Fingerprint Island. Register with PETS (Personnel Eligibility Tracking System).Prior to being fingerprinted, you must follow the following steps: You must schedule a visit to the NYCDOE HR Connect Walk-In Center, 65 Court Street, Brooklyn, NY. All Students doing fieldwork observations for more than five days in a NYC public school must be fingerprinted and have background check clearance. ![]() ![]() They are brilliant if you’re in a noisy place as they detect the note’s correct pitch through vibration, so if there’s lots of noise around, it doesn’t affect the tuner (because it isn’t reliant on a microphone). Vibration-based tuners clip on to your guitar’s headstock. It’s pretty easy: ‘get the needle in the middle’ remains our aim. ![]() Ideally, we want you to know how to tune your guitar with all three. Guitar Notes Explained: A Guide For Beginners There are 3 different types of electronic tuner. If you want to learn more about the notes of the guitar fretboard read our article: The more your guitar is ringing out a note the easier it is for the tuner to hear, so pluck lots. Most beginners are quite timid and pluck once and then wait for ages while the tuner ‘listens’ for a note that’s stopped ringing.ĭon’t do this. Which way did the needle go? If it went towards the middle, keep going! If it went away from the middle, turn the machine head in the opposite direction.Ħ – Repeat the cycle of A) pluck string B) look at tuner and C) turn machine head until the needle is in the middle. Is the needle in the middle? If not turn the machine head one way or the other.ĥ – Pluck again. Important!If your tuner is manual, then make sure your tuner is ‘listening’ for the correct string that you want to tune. If the tuner is set to ‘listen’ to a different string to the one you are tuning you may overtune the string and it will snap!Ĥ – Look at the tuner. (Most tuners default to ‘auto-detect’ the strings, but some tuners need to be manually told what string you want to tune.) The red light to the right would be lit and this would tell us the note was too ‘sharp’ (too high).Ģ – If necessary, tell the tuner the string you want to tune. If the needle was over to the right, again the green light would not be lit.The red light to the left of it would be lit, and this would tell us the note was too ‘flat’ (too low). The green light would not be lit if the needle was over to the left.We can see it’s tuning the A string (the fith string) because in the top left corner it says “5A”. (Can you see the thin, black vertical line?)īecause the needle is perfectly in the middle, the green light above it is lit. In the picture above the ‘needle’ is perfectly in the middle. You need to get the needle in the middle. ![]() It will show you with a light whether the note is too low or too high.It will show you with an oscillating ‘needle’ how far away from the note you are.It will tell you the string it thinks you’re trying to tune.You pluck a note and the tuner shows you the note you played. The interface of ALL tuners is broadly the same. (When you have a decent electronic guitar tuner you simply won’t need to worry about how to tune a guitar again.) When people ask me how to tune a guitar I always say the same thing: All things considered, electronic guitar tuners are the best option. Learn from the world's best guitar educators: Click here for our guitar courses Guitar tuning with an electronic guitar tuner How to tune a guitar using its own strings (and your ears!).How to tune a guitar using other instruments. ![]()
![]() ![]() Double click inside the Gears 5 folder, extract the.Once Gears 5 is done downloading, right click on the torrent and select “Open Containing Folder”.If you don’t have a torrent application, click here to download uTorrent. Click the download button below and you will be asked if you want to open the torrent.Visual Showcase: Play every mode in 4K and HDR at a smooth 60 frames per second on compatible machines.Play as Jack: Play as Jack, your personal flying support bot that can protect allies and damage enemies – perfect for players new to Gears. ![]() Boot Camp: New to Gears or just a little rusty? Bootcamp is a fun way to learn the ropes, from the basics to advanced combat techniques.Take on new and exciting challenges, earn awesome rewards, and show off your loot. Tours of Duty: Rank up from new recruit to four-star general in Gears Tours of Duty.Three-player Campaign Co-op: Battle alongside your friends in three-player online or split-screen co-op.Map Builder: Create custom Escape hive maps and experiences to share with and challenge your friends. Horde: Can you and four friends endure waves of ever-stronger enemies and bosses? Survive using new hero abilities, building defenses, collecting power, leveling up your skills and working as a team. With ten other game types plus new and classic maps, Versus rewards every competitive style, from casual to pro. Versus: May the best team win! Rack up points and trade up for superior weapons in Arcade, a frenetic playlist built for jump-in, over-the-top fun. Escape: Outrun the bomb, outsmart the Swarm, and escape the Hive! Escape is a new, aggressive, high-stakes co-op mode featuring a three-player suicide squad that must work together to take out enemy hives from within. With danger closing in, Kait Diaz breaks away to uncover her connection to the enemy and discovers the true danger to Sera – herself. The Swarm has corrupted the Coalition’s robot army and is descending upon human cities. ![]() ![]() ![]() ![]() El Día de Los Tres Reyes Magos (also referred to as Navidad, the Epiphany, Coming of the Three Kings, etc. The camels ferry the Three Kings from house to house, like the reindeer transport Santa. While the majority of Christians in the US recognize Christmas and present gifts on December 25th, in Spain, and many Orthodox Christian churches or countries, Christmas as we are familiar with is celebrated January 6th. In the warm tropics like Puerto Rico, it is easy for children to get one chore done before the Three Kings arrive - kids have to go outside and put some grama (grass) or hay in a box, usually a shoebox, and leave it for the camels to eat. Ya Vienen Los Reyes Magos The Three Wise Men Are Coming MayT19:49:24+00:00Christmas Navidad, Holidays, Los Reyes Magos. White Chorus Singing Spanish Carols 2011 Producciones AR Released on. Christmas Carols Songs Studio Xmas For Kids In Spain."I loved it more that Christmas, no pressure to get big presents, just a lot of family love," said Vila. Provided to YouTube by The Orchard Enterprises Los Tres Reyes Hello This blog is about the wonderful Christmas tradition called Los Tres Reyes Magos (The Three Wise Men) which takes place in Spain on the 6th of January. The holiday brings back great memories from her childhood she remembers she always got new pajamas from the Three Kings and drank hot chocolate with her family in Mexico. The first half of the file is in SPANISH. A variety of activities appropriate for levels 1 - 3. The day celebrates The Three Kings, Melchor, Baltazar and Gaspar who followed the Star of Bethlehem to visit the Baby Jesus to offer gifts of gold, frankincense and myrrh. Everything you need to teach about the Christmas tradition of Three Kings Day in Mexico in both English and Spanish Includes readings, worksheets and crafts for El Día de los Tres Reyes Magos (Three Kings Day). In Westchester County, New York, The Online Mom website founder Monica Vila was busy hiding a few small presents under her daughter's bed on the evening of January 5th, known as Víspera de Reyes, or Three Kings Eve. Three Kings Day (Da De Los Tres Reyes Magos) on January 6th is a huge celebration here in Puerto Rico even more so than Christmas Day for a lot of families. Each person will cut his/her own piece and if you get a plastic doll, the tamalada is on you! Party at your house with tamales on February 2, the Día de la Candelaria." In it, there will be one or several little plastic dolls, symbolizing baby Jesus. The truth is that Santa Claus is becoming more and more common, but even families that sign up with Papa Noel usually keep their accounts open with the Kings. Many Villancicos (similar to a Christmas carol) are also on the playlist, such as “Vamos, Vamos Pastorcito” and the all-time favorite “Mi Burrito Sabanero.” The latter has both a merengue version by Elvis Crespo and a catchy banda tune by Banda El Recodo.Houston, Texas resident Claudia Deschamps, who grew up in Mexico, recently described what her family will be doing on Three King's Day: "A Rosca de Reyes, (a large oval shaped bread with dried fruit decorations - like a King's Cake) will be bought. There is quite a debate across Spain regarding whether Santa Claus is displacing the traditional Three Kings at Christmastime in Spain. There’s also the heartfelt bolero “Regalo de Reyes” by the late Mexican singer and actor Javier Solís Luis Miguel’s rendition of “Noche de Paz,” part of his Navidades Luis Miguel album “Caspar, Melchor, y Baltasar” by Mexican trio Pandora and Thalía’s gitty “Los Reyes Magos,” part of her children’s album Viva Kids – Volumen 2, to name a few. The playlist includes the timeless holiday track “Cantares de Navidad” by the Puerto Rican group Trio Vegabajeño, which was originally composed in the early 1950s and forms part of Bad Bunny’s album El Último Tour del Mundo. In honor of Three Kings Day 2023, Billboard has compiled a playlist of some traditional classics you and yours can use to set the festive mood. See more ideas about spanish holidays, spanish christmas, how to speak spanish. 6 Latin Collaborations We Want to See in 2022: Rauw Alejandro, Kali Uchis & More Explore Kathleen Taylors board 'los tres reyes', followed by 108 people on Pinterest. ![]() ![]() 13, 14, 15 Over the past years, we, as well as others, have identified heterozygous variants in BICD cargo adaptor 2, also known as bicaudal D homolog 2 ( Drosophila) ( BICD2 ), associated with dominantly inherited spinal muscular atrophy, lower extremity predominant 2A and 2B (SMALED2A/2B ). These genes, although functionally heterogeneous, have revealed common molecular mechanisms underlying the pathology of dominant HMNs, such as protein misfolding and aggregation, 7, 8, 9 disrupted axonal transport, 9, 10, 11, 12 and mitochondria dysfunction. Variants in more than 60 genes have been associated with autosomal-dominant forms of HMN or CMT2, which are phenotypically very similar (see “Muscle Gene Table” and “Inherited Neuropathy Variant Browser” in Web Resources). Notwithstanding that, a successful genetic diagnosis is possible only in about half of the individuals with HMN/CMT2. The integration of next-generation sequencing (NGS) technologies into routine genetic diagnostics and the ensuing yield of novel disease genes has greatly expanded the number of loci associated with axonal neuropathies. 2, 3, 4 This variability not only results in complex phenotypic categorizations but also in diagnostic challenges and potential misinterpretation of genetic findings. Clinically, HMNs/CMT2 present with extreme heterogeneity in terms of onset, clinical course, associated neurological features (i.e., sensory or cerebellar involvement), and other co-presenting signs, including seizures, fractures, and respiratory distress, among others. 1 The cardinal phenotype of these entities is a length-dependent motor neuropathy that predominantly affects the distal foot and peroneal muscles and results in foot abnormalities or deformities and gait disturbance. The distal hereditary motor neuropathies (HMNs) are characterized by pure motor neuropathy, whereas the axonal Charcot-Marie-Tooth neuropathy (CMT2) have both motor and sensory involvement. 1 Classically, they are classified into two subgroups depending on the affected fiber type. Hereditary axonal neuropathies are a heterogenous group of disorders characterized by normal or moderately reduced nerve conduction velocities. ![]() Our results not only reinforce the existing link between Golgi fragmentation and neurodegeneration but also demonstrate that pathogenic variants in GBF1 are associated with HMN/CMT2. Consistent with the described role of GBF1 in Golgi function and maintenance, we observed marked increase in Golgi fragmentation in primary fibroblasts derived from all affected individuals in this study. We demonstrate that GBF1 is present in mouse spinal cord and muscle tissues and is particularly abundant in neuropathologically relevant sites, such as the motor neuron and the growth cone. GBF1 is mainly involved in the formation of coatomer protein complex (COPI) vesicles, maintenance and function of the Golgi apparatus, and mitochondria migration and positioning. GBF1 encodes a guanine-nucleotide exchange factor that facilitates the activation of members of the ARF (ADP-ribosylation factor) family of small GTPases. Three individuals had additional distal sensory loss. Electrophysiological studies confirmed axonal damage with chronic neurogenic changes. Affected individuals show HMN/CMT2 with slowly progressive distal muscle weakness and musculoskeletal deformities. ![]() Other known HMN/CMT2-implicated genes were excluded. Genomic sequencing analyses in seven affected individuals uncovered four distinct heterozygous GBF1 variants, two of which occurred de novo. Here, we report the identification of pathogenic variants in GBF1 (Golgi brefeldin A-resistant guanine nucleotide exchange factor 1) in four unrelated families with individuals affected by sporadic or dominant HMN/CMT2. The genetic cause for about half of the individuals affected by HMN/CMT2 remains unknown. Distal hereditary motor neuropathies (HMNs) and axonal Charcot-Marie-Tooth neuropathy (CMT2) are clinically and genetically heterogeneous diseases characterized primarily by motor neuron degeneration and distal weakness. ![]() ![]() ![]() ![]() If you still carry around your membership card in your wallet for old times sake, we salute you. That one time Heinz tried to get a little experimental and had us all begging our mamas to buy us purple goop to squirt all over our french fries.Ĭoca Cola was bugging with this one! We all know nothing beats that classic lemon lime taste that comes in the green bottle.īefore the days of “Netflix and Chill,” there was the honor and privilege to walk the aisles of the greatest video store in the world to pick out your favorite rental flicks for the weekend. Here are all the things we were blessed to have known even though our children never will. ![]() Disney Channel and recall all the times our young, sweet souls were truly happiest.īut in the midst of all of the reminiscing, at some point we realize one thing: our kids will never ever know some of the greatest things to come out of the 90s. We hit up our group chats to launch into another segment of the lifelong debate over Nickelodeon vs. 4.Every now and then, children birthed in the greatest era-the 90s (duh!)-are struck in their little nostalgic hearts as they take a stroll down memory lane. Hilton would go on to star in movies, release her own fragrance, dabble in the music business, and invest in real estate around the globe. The fish out of water reality series would go on to have five seasons and establish both women in the spotlight. At the time of its release, Hilton and fellow rich kid Nicole Ritchie were starring in their own show The Simple Life. While it could have ended her career, it did the reverse. Things really went next level for Hilton in 2003 when her sex tape with Rick Solomon was leaked.ġ Night in Paris became one of the most talked-about pop culture moments and was the biggest celebrity sex tape since Pamela Anderson and Tommy Lee. If there was a major event, be it a fashion show, new club opening, or lavish celebrity party, she was there. The hotel socialite did some modeling to raise her profile but was more known for just being everywhere during the early 00s. Polly Pocketįamous for being famous, Paris Hilton was the original Kim Khardasian. To make life a little easier, we have gathered together 20 things that are sure to placate your 2000s nostalgia feelings and maybe even bring a tear to your eye. You can search for anything and everything from your time growing up. So if you are getting nostalgic for the 2000s don’t fret, as the internet is here to satisfy your feelings. Kids these days with their TikTok and streaming services will never understand what it felt like to have to wait hours to download one song. The early 2000s gave us CDs, DVDs, Paris Hilton, Limewire, Magic the Gathering, and the iPod, just to name a few things. So many crazy trends and things that are no longer in use came about during this period. It was also the birth of the reality star. Entertainment was available to most people at the touch of a button. Pop culture was coming to the fore with the advancement of the internet. For most Millenials, especially those born in the early 90s, the 2000s will hit you in the feels. ![]() It’s funny to think about the early 2000s sparking nostalgic feelings, but considering we are already in 2022, it rings true. ![]() ![]() ![]() Some people prefer to buy the first inexpensive antenna they see on Amazon, set it up, and see what channels automatically become available to them. To benefit from it, however, you need a TV antenna, which is why we created this guide. Over-the-air TV, or OTA, is a capability already built into your TV that can increase the number of channels available to you. Key considerations Understanding over-the-air TV If you’re trying to reach a signal that’s far away, it’s best to purchase an antenna with more range than you think you need. We compiled the specs of the best TV antennas so you can easily discover what is available and what to shop for. For this to occur, a strong signal is necessary, which is why it’s important to understand what to look for when shopping for a TV antenna. You can choose from outdoor antennas, indoor HDTV antennas, and amplified HDTV antennas, to name a few.įor quality viewing, you will want an antenna that delivers the best reception possible. If you have decided to purchase a TV antenna, the question you may be asking is which one is right for your situation. In step with modern technology, most antennas used today are digital in nature. The rabbit ears of yesteryear have been replaced with paper-thin sheets that you simply hang near a window and allow them to work their magic. With the right antenna situated in or above your home, you may be able to pick up TV signals from live stations in your area such as NBC, CBS, ABC, PBS, and Fox without having to pay for subscriptions to those channels. Cord cutters have begun to rethink the concept of the “antiquated” TV antenna because they have realized that owning a TV antenna is an easy way to access free local TV channels without paying for costly subscriptions and streaming services. For these low power VHF TV stations, a ClearStream® 5 VHF TV antenna may be required as a supplement. However, some DTV stations that have reverted back to VHF frequencies may have also cut their power by over 90%. ![]() Advancements in efficiency mean that up to 98% of the signal actually makes it to the line, rather than being lost to impedance mismatches.įor most locations, the ClearStream Eclipse®, ClearStream FLEX®, ClearStream 1MAX®, ClearStream 2MAX®, or ClearStream 4MAX® will receive all HDTV signals in the area. With other compact TV antennas, as little as 10% of the signal may actually reach the tuner. Popular digital antennas may claim high “peak” gains on specific frequencies, but the ClearStream® models are consistently powerful across the entire DTV spectrum. ![]() Ultra-efficient design now allows powerful TV antennas to be smaller than ever thought possible. Designed for reception on high-VHF (Ch 7-13) and core UHF (Ch 14-51) channels. The first all-new HD TV antennas optimized for the post-2009 digital frequencies. New breakthroughs in efficiency and size. ![]() |